keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
β-Amyloid (25-35) (Aβ25-35) 是一种阿尔茨海默氏淀粉样蛋白β肽的Aβ(25-35) 片段,在培养细胞中显示出神经毒性作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 498 | 现货 | ||
5 mg | ¥ 1,530 | 现货 | ||
10 mg | ¥ 2,360 | 现货 | ||
25 mg | ¥ 3,990 | 现货 | ||
50 mg | ¥ 5,680 | 现货 | ||
100 mg | ¥ 7,950 | 现货 |
产品描述 | β-Amyloid (25-35) (Aβ25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells. |
体外活性 | β-Amyloid (25-35) 的氨基酸序列为NH2-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-COOH,首个Gly代表第25个氨基酸,末尾的Met代表第35个氨基酸。本研究首次探讨了该多肽在凝胶状态下的特性。研究表明,Amyloid beta-peptide(25-35)能够对分离出的脑线粒体产生凋亡效应,其中methionine-35的氧化还原状态对于程序性细胞死亡途径及其毒性事件的诱导起着关键作用[2]。同时,通过振动吸收光谱和ECD进行了比较研究。此外,利用振动吸收光谱和VCD光谱技术也对Aβ(25-35)多肽膜的构象偏好进行了探究[1]。 |
体内活性 | The Alzheimer' s disease (AD) model group present with spatial learning and memory impairments. CDS and donepezil administration significantly ameliorate the Aβ25–35 peptide-induced memory impairment in both Morris water maze (P?0.05) and passive avoidance task (P?0.01) compared to the AD model group[3]. Rats are injected with Aβ25–35 peptide intracerebroventricularly and compound Danshen (CDS) are subsequently administered once daily for 23 days. Rats' behavior is monitored using Morris water maze and passive avoidance. Real time PCR and Western blotting are used in determining amyloid precursor protein (APP), β-site APP cleaved enzyme-1(BACE1), Presenilin-1 (PS1), Insulin-degrading enzyme (IDE) and neprilysin (NEP) in hippocampus. |
别名 | β-Amyloid peptide(25-35), Aβ25-35, BETA-淀粉样蛋白片断25-35, Amyloid beta-peptide(25-35) |
分子量 | 1060.27 |
分子式 | C45H81N13O14S |
CAS No. | 131602-53-4 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 3.33 mg/mL (3.14 mM), Sonication is recommended.
DMSO: 97 mg/mL (91.49 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 0.9432 mL | 4.7158 mL | 9.4316 mL | 23.5789 mL |
DMSO | 5 mM | 0.1886 mL | 0.9432 mL | 1.8863 mL | 4.7158 mL |
10 mM | 0.0943 mL | 0.4716 mL | 0.9432 mL | 2.3579 mL | |
20 mM | 0.0472 mL | 0.2358 mL | 0.4716 mL | 1.1789 mL | |
50 mM | 0.0189 mL | 0.0943 mL | 0.1886 mL | 0.4716 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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